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What is MRD, and why is it important in acute lymphoblastic leukemia?

Sebastian Giebel

March 23, 2022

During the ESH 3rd How to Diagnose and Treat Acute Leukaemias, Know ALL spoke with Sebastian Giebel, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, PL. We asked, What is measurable residual disease (MRD), and why is it important in acute lymphoblastic leukemia?

Giebel begins by discussing detection methods, including flow cytometry or molecular techniques which are used to precisely monitor responses. He highlights the huge prognostic impact MRD can have for patients. Finally, he outlines the bispecific antibody blinatumomab, used as a therapy to eradicate MRD.